Alpha Tau is the first company to develop a cancer therapy that releases an alpha radiating material for diffusion into solid tumors.

• Alpha DaRT utilizes alpha radiation for the local treatment of solid tumors, and is designed to release short-lived alpha-emitting atoms in the tumor, overcoming the traditional limitation of alpha radiation’s short therapeutic range, and aiming to achieve the holy grail of delivering a high but conformal dose of radiation inside the tumor while sparing surrounding healthy tissue
• In its first US pilot study, a multi-center skin cancer study led by Memorial Sloan Kettering in NY and published in the JAMA Network Journal, the company observed a 100% complete response rate at 12 and 24 weeks after treatment, with no product-related serious adverse events.
• In more recent long-term data released, an analysis of four feasibility trials in 71 patients with unresectable skin and head and neck cancers demonstrated 89% CR, two-year local recurrence-free survival of 77%, and no treatment-related grade 2 or higher late-onset toxicity.
• The Company has launched its first US pivotal study for FDA approval (in recurrent cutaneous squamous cell carcinoma), as well as an initial feasibility study in pancreatic cancer in Montreal (which read out very encouraging initial interim data, with strong safety and feasibility and initial signs of potential efficacy), and a trial in combination with Keytruda (pembrolizumab), all currently underway.
• The Alpha DaRT has already received two Breakthrough Device Designations from the FDA: one in skin SCC of the skin or oral cavity without curative standard of care, the other in recurrent GBM. The product is approved for marketing in Israel, for the treatment of squamous cell carcinoma of the skin or oral cavity, and has applied in Japan for marketing authorization in head & neck cancers.
• In pre-clinical research, Alpha DaRT has demonstrated success in controlled destruction of multiple tumor types, with >10 years of pre-clinical research generating 24 published peer-reviewed studies. The studies have also demonstrated signs of triggering a broader immune system effect and potential boost to immunotherapy treatments